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In scopul diminuarii acestui risc, se recomanda un somn nocturn neintrerupt. Riscul de afectare a vigilentei este mai mare daca durata somnului este insuficienta.dependenta fizica  si  psihica, chiar  la  dozele terapeutice, cu  sindrom de  abstinenta sau fenomen de rebound la intreruperea tratamentului;Doza este strict individualizata, dozel